Various analytical techniques are currently used for the detection and quantitation of residual solvents in pharmaceutical powders (GC, GC-MS, HPLC etc…). However, these techniques are time consuming, require highly qualified personnel and are incompatible with production environments.
Sample preparation, including pre-concentration step(s), is also time consuming and requires large quantities of solvent. The TV9000 is a new instrument designed for the measure of total volatiles. The analytical method developed allows for a rapid (2 minutes per analysis) and easy at-line monitoring of the elimination of solvents. In this method, volatile compounds are adsorbed onto a SPME fiber placed at the outlet of the drying system (rotavapors), then directly desorbed into the TV9000. The results obtained are plotted on a chart to follow the elimination of a solvent from a batch of pharmaceutical or chemical products.

The TV9000 software was developed using the latest programming technology available. A simple Graphic User Interfaces (GUI) makes at-line analysis possible without any analytical knowledge. The software gives users instructions for the next step. The results can be seen immediately on the screen without having to interact in to the calculation process. Easy to use without compromising functionality, very simple to understand the software has been designed to accommodate non specialized personnel. Multiple drying stations (Rotavapors) can be handled with a single TV9000. With two levels of users available the software adapts itself to the operator’s knowledge and capabilities Method
sequences can be easily created by the system manager. User dependent rights are given so that no method can be changed during a drying process.