Various analytical techniques are currently used for the detection and quantitation of residual solvents in pharmaceutical powders (GC, GC-MS, HPLC etc…). However, these techniques are time consuming, require highly qualified personnel and are incompatible with production environments.
Sample preparation, including pre-concentration step(s), is also time consuming and requires large quantities of solvent. The TV9000 is a new instrument designed for the measure of total volatiles. The analytical method developed allows for a rapid (2 minutes per analysis) and easy at-line monitoring of the elimination of solvents. In this method, volatile compounds are adsorbed onto a SPME fiber placed at the outlet of the drying system (rotavapors), then directly desorbed into the TV9000. The results obtained are plotted on a chart to follow the elimination of a solvent from a batch of pharmaceutical or chemical products.