The IFC PAL platform

With the raising interest in the discovery of new compounds that may develop into safe and effective drugs, there is a growing need for efficient separation,
isolation and purification of small or large quantities of compounds. Quick purification represents an essential step between synthesis, screening and characterization of new potential pharmaceutical candidates.

CTC Analytics supplies instruments to customers which make the operation of sample processing simple and transparent. The IFC autopurification platform was developed based on the proven reliability and productivity of our PAL series of LC/LC-MS sample loaders.

The IFC PAL combines sample injection and fraction collection with unmatched capacity and versatility. The dual-probe design allows the complete separation of injection and collection flow paths. High concentrated samples can never cross-contaminate low concentrated fractions.

Additionally the commonly used 3-way fraction collector diverter valve is replaced by a unique sidehole syringe valve which enables an extremely low dead volume between valve and collection outlet. This special diverter
valve design further prevents fraction carryover. The IFC PAL dual-probe design provides true high throughput processing never achieved before by
conventional autopurification solutions. During fraction collection the next sample injection is already prepared and executed. Overlapping the two processes results in dramatically faster cycle times compared to single-probe
systems.